For many years Tripos^TM and BioSolveIT had a successful development/distributor partnership and served scientists around the world with cutting-edge virtual screening technology. However, the ability to now work directly with users worldwide offers a great opportunity to stay ahead of the competition and continue to be the premier supplier of drug discovery software.

So what consequences will this have for our customers? Here are the most important ones:

	Direct contact with the software developers: 'Tell us your needs and they will be considered'
	Instantaneous access to updates and upgrades: 'BioSolveIT follows an aggressive release schedule'
	Independence from other software: 'Now it's your choice of environment in which to use FlexX'
	New user interfaces: 'Both an interface in MOETM and a GUI for the standalone version are in development'

Great care has been taken to ensure that the change of relationship will take place virtually seamlessly for the existing customer base. Existing contracts will not be affected by the change. These users will continue to be serviced as defined in their respective contracts. This includes support, updates and upgrades. BioSolveIT will support Tripos in order to ensure such services. New contracts, however, will be issued by BioSolveIT.

Customers frequently compliment us for our support that goes way beyond the ordinary. For example, Robert Kiss from Semmelweis University in Hungary recently commented: "BioSolveIT's support is outstanding!" To benefit from the highest level of service, please visit our web site, and order your evaluation copy of FlexX, FlexS or FTrees today. Or, if you have specific requirements for special development or consulting in mind, write to contact@biosolveit.de. We are custom software solution providers and are confident that we can offer you the best possible solution to your problem.

Apart from the booth, there will be numerous scientific presentations related to our technology. We encourage you to consider these as you plan your itinerary. This overview may serve as a guideline:

	Wendy Sanderson (Johnson & Johnson) COMP 21 — Complementarity of FTrees and Tanimoto similarity, clustering, and Bayesian learning in the search for Alpha 7 nAChR ligands 8:30 AM-12:00 PM, Sunday, 10 September 2006 Moscone Convention Center — Room 236
	Juri Paern (ZBH) COMP 23 — 2D visualization and constraint-driven enumeration of chemical fragment spaces 8:30 AM-12:00 PM, Sunday, 10 September 2006 Moscone Convention Center — Room 236
	Markus Boehm (Pfizer) CINF 11 — Similarity searching in large virtual chemistry spaces derived from synthetically accessible combinatorial libraries 9:00 AM-11:30 AM, Sunday, 10 September 2006 Moscone Convention Center — Room 125
	Holger Claußen (BSI) COMP 178 — Recent developments in the FlexX family 1:00 PM-4:15 PM, Tuesday, 12 September 2006 Moscone Convention Center — Room 236
	Iris Antes (MPI) COMP 176 — Inhibitor based refinement of homology modeled protein structures for molecular docking 1:00 PM-4:15 PM, Tuesday, 12 September 2006 Moscone Convention Center — Room 236
	Christian Lemmen (BSI) CINF 79 — Recent advances in molecular docking 2:00 PM-5:50 PM, Tuesday, 12 September 2006 Moscone Convention Center — Room 122
	Andreas Kämper (MPI) COMP 327 — Use of metal coordination geometry to improve FlexX docking 8:30 AM-11:45 PM, Wednesday, 13 September 2006 Moscone Convention Center — Room 236
	Iris Antes (MPI) BIOL 211 — DYNAPRED: Combining docking and sequence based methods for the prediction of MHC/peptide complexes for vaccine design 4:30 PM-6:30 PM, Wednesday, 13 September 2006 Moscone Convention Center — Hall D (Poster)

Please visit us at the booth to learn about the latest developments at BioSolveIT. A selection of planned presentations:

	Mouse Click Docking: A GUI for FlexX that will set new standards in user-friendliness and functionality
	FlexX Loves MOE: CCG's renowned Molecular Operating Environment supports FlexX through an intuitive interface
	FTrees Made Easy: A GUI for FTrees facilitating million-compound screening
	Warp Speed Docking: The new performance booster module, FlexX-Screen
	and many more

The FlexX-Screen module has been developed with a focus on screening millions of compounds. It incorporates two novel developments: the FlexX-Scan functionality by Schellhammer et al. (PROTEINS: Structure, Function, and Genetics 2004, vol57, p504-517) and a heavily exploitable caching strategy. The two have been merged in a perfect symbiosis - although they can still be activated and configured separately. Apart from making one or two settings, the user will simply notice that docking has already completed. As an example, in-house experiments on 800,000 compounds completed within 150 minutes on 300 CPUs. This means you can easily dock (with the same set-up) 7-8 million compounds a day! Our sophisticated clientele has been used to the speed of FlexX for a decade already. Robert Kiss from Semmelweis University in Hungary says: "We chose FlexX for the world's largest structure-based in-silico screening for its speed and reliability. And right we were!" In the future, using FlexX-Screen, immensely large screening runs will take just a fraction of your valuable time. The module will be available with the advent of FlexX Release 2.1 later this year. Interested users should please contact us now by email.

If you have any questions or know of any tips and tricks yourself that you would like to share with the FlexX user community, we would appreciate your input at FlexX-info@BioSolveIT.de.